All cells within complex living organisms communicate through a constant exchange of biological signals. Through this dynamic communication network, cells are able to coordinate their tasks, form complex tissues, and adapt to environmental conditions. CIBSS aims to understand and communicate in this molecular language of life. By developing new tools to control signalling, we strive to accelerate innovation for health and sustainable agriculture.

From molecules to cells and from cells to tissues and organs, signal integration is at the core of how cells make decisions – both good and bad ones.  Signals from the environment, from neighbouring cells and from within the cell interact across spatial and temporal scales. To respond appropriately, cells must integrate, store, and transmit this multitude of inputs. CIBSS investigates the mechanisms that govern how signals are processed and decisions are made.

Central concepts CIBSS addresses are contextualization, compartmentalization and signalling memory: How can the same signal trigger different responses depending on what other signals are present? Why do identical cells in different environments react differently to the same signal? How is signalling information molecularly stored and how does this influence how the cell interprets subsequent signals? And how does the organisation of the signalling machinery into compartments control cellular decisions and memory?

To answer these questions, CIBSS researchers develop tools for the precise control of signals, including chemical and light-controlled systems, that allow us to speak the molecular language of life. These achievements are accompanied by research into the ethical, legal and social aspects of signalling technologies. Our work is opening up new paths for basic research and accelerates innovations in health and sustainable agriculture.

CIBSS combines the expertise of research groups at the University of Freiburg, the Max Planck Institute of Immunobiology and Epigenetics and the Freiburg University Medical Centre and collaborates with national and international research partners. With an interdisciplinary approach regarding research topics, model systems and technologies, CIBSS is in the unique position to address questions that are otherwise inaccessible to achieve a deeper understanding of how signals are integrated and decisions are made.

Involved Institution:

• Max Planck Institute of Immunobiology and Epigenetics