Within four closely connected Research Areas, we will develop standards for the engineering of biomolecular functions using DNA nanotechnology and protein design. These will be implemented in the context of self-organizing molecular assemblies, synthetic cells, designer cells, and organoid systems. Applications for these engineered systems range from designed biomolecular machines for biosynthesis and smart materials to biomedical microrobots and novel pattern-based therapeutics to the control of cellular differentiation and organ formation. To enable cross-fertilization of the different research areas across scales, researchers will be organized into four dedicated focus groups around Research Themes devoted to specific hallmarks of life – the generation of form and structure, motility, information processing, and evolution.

To tackle high-potential application opportunities, complementary teams of researchers will focus on highly ambitious mission driven projects (so-called M-Projects), such as the realization of pattern-based therapeutics, biomedical nanorobots, or programmable biosynthetic assembly lines. Our efforts will be enabled by several closely interlinked support structures: a Technology Hub, dedicated makerspaces (Biomolecular Design Studios), an AI Core Unit, and startup support. These will ensure access to cutting-edge technology with professional support, easy exchange of components, protocols and standards among the researchers in the cluster and with the Biosystems Design Munich scientific community worldwide, the effective application of rapidly evolving AI approaches, and a ready translation of fundamental research results into applications. This will be supported by makerspace facilities and dedicated open labs, which will act as interfaces with the public for engagement and co-creation activities. A wide range of structural measures will support junior researchers at all career stages, promote equity and diversity, ensure sustainability, provide quality control, and facilitate professional research data management.

Involved Institutions:

• Helmholtz Munich – German Research Center for Environmental Health
• Max Planck Institute of Biochemistry (MPIB)